Electron-hole coherent states for the Bogoliubov-de Gennes equation

We construct a new set of generalized coherent states, the electron-hole coherent states, for a (quasi-)spin particle on the infinite line. The definition is inspired by applications to the Bogoliubov-de Gennes equations where the quasi-spin refers to electron- and hole-like components of electronic excitations in a superconductor. Electron-hole coherent states generally entangle the space and the quasi-spin degrees of freedom. We show that the electron-hole coherent states allow obtaining a resolution of unity and form minimum uncertainty states for position and velocity where the velocity operator is defined using the Bogoliubov-de Gennes Hamiltonian. The usefulness and the limitations of electron-hole coherent states and the phase space representations built from them are discussed in terms of basic applications to the Bogoliubov-de Gennes equation such as Andreev reflection.Comment: 18 page

Coherent states and wave packet dynamics for the Bogoliubov-de Gennes equations

We investigate generalizations of coherent states as a means of representing the dynamics of excitations of the superconducting ground state. We also analyse the propagation of generalized coherent state wave packets under the Bogoliubov-de Gennes Hamiltonian. The excitations of the superconducting ground state are superpositions of electron and hole quasi-particles described by the Bogoliubov-de Gennes equations, that can only exist at energies outside the band gap. A natural generalization relevant to the excitations of the superconducting ground state is the tensor product of canonical and spin coherent states. This state will quickly become de-localized on phase space under evolution by the Bogoliubov-de Gennes Hamiltonian due to the opposite velocities of the quasi-spin components. We therefore define the electron-hole coherent states which remain localised on phase space over longer times. We show that the electron-hole coherent states though entangled retain many defining features of coherent states. We analyse the propagation of both product and electron hole coherent states in a superconductor with a spatially homogeneous superconducting band gap. The dispersion relation indicates that wavepackets defined on the band gap have a zero group velocity, but we will show that interference effects can create states on the band gap that propagate at the Fermi velocity. We also consider the two semiclassical, short wavelength regimes, hbar->0$ and the large Fermi energy limit mu->infinity. In general these limits produce behaviour analogous to the canonical coherent states except for isolated cases. Finally we analyse the dynamics of the Andreev Reflection of a Gaussian wavepacket incident on a discontinuous normal-superconducting interface. We show that restricting the energy bandwidth of the incident state inside the superconducting band gap precludes the wavepacket from fully entering the superconducting region. We again consider the two semiclassical regimes

Coherent states and wave packet dynamics for the Bogoliubov-de Gennes equations

We investigate generalizations of coherent states as a means of representing the dynamics of excitations of the superconducting ground state. We also analyse the propagation of generalized coherent state wave packets under the Bogoliubov-de Gennes Hamiltonian. The excitations of the superconducting ground state are superpositions of electron and hole quasi-particles described by the Bogoliubov-de Gennes equations, that can only exist at energies outside the band gap. A natural generalization relevant to the excitations of the superconducting ground state is the tensor product of canonical and spin coherent states. This state will quickly become de-localized on phase space under evolution by the Bogoliubov-de Gennes Hamiltonian due to the opposite velocities of the quasi-spin components. We therefore define the electron-hole coherent states which remain localised on phase space over longer times. We show that the electron-hole coherent states though entangled retain many defining features of coherent states. We analyse the propagation of both product and electron hole coherent states in a superconductor with a spatially homogeneous superconducting band gap. The dispersion relation indicates that wavepackets defined on the band gap have a zero group velocity, but we will show that interference effects can create states on the band gap that propagate at the Fermi velocity. We also consider the two semiclassical, short wavelength regimes, hbar->0$ and the large Fermi energy limit mu->infinity. In general these limits produce behaviour analogous to the canonical coherent states except for isolated cases. Finally we analyse the dynamics of the Andreev Reflection of a Gaussian wavepacket incident on a discontinuous normal-superconducting interface. We show that restricting the energy bandwidth of the incident state inside the superconducting band gap precludes the wavepacket from fully entering the superconducting region. We again consider the two semiclassical regimes

Mapping the human genetic architecture of COVID-19

The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3–7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease

Mapping the human genetic architecture of COVID-19

The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3,4,5,6,7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease